Thom Mayne founded Morphosis in 1972. As design director and thought leader of Morphosis, Mayne provides overall vision, project leadership and direction to the firm. With Morphosis, Mayne has been the recipient of the 2005 Pritzker Architecture Prize, 25 Progressive Architecture Awards and over 100 American Institute of Architecture Awards. Morphosis has been the subject of various group and solo exhibitions throughout the world, including a large solo exhibition at the Centre Pompidou in Paris in 2006.

Throughout his career, Mayne has remained active in the academic world. In 1972, he helped to found the Southern California Institute of Architecture. Since then, he has held teaching positions at many institutions around the world. His commitment to the education of young designers has not wavered. Currently, he holds a tenured faculty position at the UCLA School of Arts and Architecture.